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Shares of biotech company Amgen (NASDAQ:AMGN) jumped 5.3% in the morning session after the company reported strong fourth-quarter results. Amgen exceeded analysts' revenue expectations this quarter, and its full-year revenue guidance came in slightly higher than Wall Street's estimates. On the other hand, its full-year EPS guidance slightly missed, and its EPS was in line with Wall Street's estimates. Overall, this quarter was mixed with better-than-anticipated sales but mediocre profitability.

GSK Plc's U.S.-listed shares surged Wednesday after the pharmaceutical firm boosted its long-term outlook and launched a $2.5 billion stock buyback on the back of optimism about sales of its new drugs.

U.S. equities were mixed at midday, slowed by new Chinese tariffs on U.S. goods and weak tech results.

Shares of Super Micro Computer surged for a second straight session after it said it would give a second-quarter business update next week.

Shares of Johnson Controls International surged to lead S&P 500 gainers on Wednesday morning after the company's first-quarter results topped estimates and it announced a new CEO.

Match Group shares tumbled Wednesday, a day after the online dating service provider named a new CEO and offered a soft outlook as sales for most of its units declined.

US stocks pulled back against a backdrop of mixed earnings and the outbreak of a trade war with China.

Chipotle Mexican Grill shares fell Wednesday, a day after it missed revenue and same-store sales estimates, and tried to downplay concerns about the effects of possible U.S. tariffs.

Google's parent company and other tech stocks are weighing on a mixed Wall Street Wednesday as the focus swings back toward how much profit businesses are making. Alphabet fell 8.8% even though Google’s parent company reported stronger profit for the latest quarter than analysts expected. Pressure is growing on Alphabet from Wall Street, and “investors will be asking what new products will be emerging to warrant the higher level of investment,” according to UBS analysts led by Stephen Ju.

Bloomberg said the move would impact roughly 80 jobs, with some of the affected employees transitioning to new roles, while others leaving the company. The change was communicated during a town hall meeting, the sources added, with Macquarie planning to sell positions it amassed through U.S. debt capital markets activities over the next two years. Macquarie, Australia's largest asset manager, generates revenue through infrastructure ownership, commodity trading in sectors like oil and gas, managing capital raisings for other companies, and offering home loans in its domestic market.